NOTE: Recent press about CCleaner indicates it may represent a privacy concern.
CCleaner is a feature-rich system optimization and privacy tool. The program cleans unused, temporary and log files from your system, as well as traces of online activities such as Internet history and flash cookies. The program contains startup controls for Windows, major internet browsers and context menu entries. Includes a separate registry cleaner, duplicate search, system restore tool and can wipe both deleted files and drive free space for security.
A 64-bit version is available (within the folder). Monitoring functions are only available in the pro version.
Additional cleaner rules can be using an unofficial set of community-developed set. It should be noted that many of these rules are alpha and the developers will not provide support for these rules, a thread in the users forum is dedicated to supporting the add-on rules.
Alternatively, ccPortable is also available.